Supplements and enzymes for the FODMAP diet

One of the digestive enzymes that I used first when I started the low FODMAP diet was lactase enzymes.

Even a bit before I started the FODMAP diet because I learned that I had a lactose intolerance two years before my IBS diagnosis.

I was ecstatic when I learned of the existence of lactase supplements.

With these enzymes, I am able to enjoy a cappuccino or an ice cream in a restaurant without having to search for a lactose-free option and that is amazing.

Some time ago, I was clicking around on the website of Intoleran, one of the brands of lactase supplements that I use, and I suddenly saw a new category “FODMAP” on their website.

Intoleran added several supplements to their product range that can be used to tolerate foods from several FODMAP groups better!

I could hardly believe it at first, would it be possible to eat FODMAP-rich foods again without problems?

I contacted Intoleran and they sent me their FODMAP enzymes, so I could test them for you.

This blog was written in collaboration with Intoleran. This doesn’t have any influence on my opinion about these products. I have been using Intoleran’s lactase supplements for years and I write about their products because I believe they can be valuable to people with IBS.

The links in this article are affiliate links. That means that I get a small compensation when you order the products through one of these links. 

The FODMAP enzymes from Intoleran

Intolean has four different supplements that can help with tolerating FODMAPs:

Lactase enzymes (lactose)

Lactase enzymes help to break down lactose in your intestines. Most of you will probably already be familiar with this supplement, so I won’t go into depth about it in this blog.

If you want to read more about lactase supplements, you can do so in this blog.

The lactase capsules from Intoleran are available in the following strengths: 

Fructan enzyme: fibractase

The Fibractase supplement from Intoleran contains the enzyme alpha-galactosidase.

The fibractase supplement contains an enzyme that helps your body break down fructans and galactans. Two FODMAP groups that quite some people experience symptoms from.

Fructans are found in garlic, onion, wheat, and several fruits. Galactans are found in legumes, several kinds of nuts, and several vegetables.

Together they form a large group of products and the fibractase supplements can help you to break these FODMAPs down.

One capsule of Fibractase contains 1.200 units of alpha-galactosidase: 

Fructose enzyme – Fructase

Fructase is a supplement that can be very helpful to people with a fructose-intolerance or people who simply don’t tolerate the FODMAP-group fructose very well.

This supplement contains the enzyme xylose isomerase can help to break down fructose.

Fructose can be found in several fruits and vegetables, dried fruit, and a lot of industrially processed foods. Fructose is often added to cookies and sweets because it is a cheap sweetener.

For people with IBS, fructose usually leads to problems when the amount of fructose in a food is higher than the amount of glucose in it. Because of that reason some fruits are low in FODMAPs (because they contain more glucose than fructose) and other fruits are high in FODMAPs.

Processed foods that contain the ingredients fructose, fructose-glucose syrup, or high fructose corn syrup are also high in FODMAPs.

Fructase could be helpful to break down the FODMAP-group fructose. Note: when you have a hereditary fructose intolerance, a very rare disease, you cannot use these supplements. 

Important: this product has not been evaluated by the Food and Drug Administration yet. It is not intended to diagnose, treat, cure, or prevent any disease.

Always test for yourself if the supplement works for you.

One capsule of Fructase contains 7500 units xylose isomerase.

You can buy the Fructase enzymes in Intoleran’s webshop. One package contains 36 capsules and costs 34.99.


Finally, Intoleran has a combination supplement containing all of the supplements mentioned above Quatrase 10.000. The Quatrase capsules contain the enzymes Alpha galactosidase, Xylose isomerase, Lactase, and Invertase.

Invertase is a supplement for a sucrose / sucralose intolerance and helps to split sucrose and sucralose.

Quatrase is handy when you react to several FODMAP groups because it contains several different enzymes.

One capsule Quatrase 10.000 contains:

  • 1.200 units of the enzyme alpha-galactosidase (for fructans and galactans)
  • 7.500 units of the enzyme xylose isomerase
  • 10.000 FCC lactase (for lactose)
  • 500 units invertase (for saccharose)

You can buy the Quatrase supplement in Intoleran’s webshop. One package contains 36 capsules and costs 49.49.

The use of the supplements

For all supplement counts, just as for lactase supplements, it is important to test for yourself if it works for you and how many supplements you need to not get any symptoms.

This depends on the amount that you eat and also on your level of intolerance for the FODMAP group. This differs per person.

Intoleran advises taking one to three supplements right before your meal.

The supplements work for half an hour, so if you eat several courses in a restaurant for example, you have to take new supplements with every course. You can use several capsules per day, up to 15 per day.

FODMAP supplements -

My experience with the FODMAP supplements

The FODMAP groups that give me the most problems are the fructans and galactans and therefore I tested these groups most extensively.

In the beginning, I was a bit too enthusiastic with the supplements. I thought “Maybe I will suddenly be able to eat everything again, so let’s just try” and I tested a few combinations that were a bit too extreme.

I ate a plateful of pasta (wheat, not gluten-free) that also had some garlic and onion in it. I can tell you, even with two capsules of fibractase, that still gave me a bad stomach ache.

I also ate a big burek, a very big phyllo dough pastry filled with white cheese. This contained both wheat and lactose and also here two pills were not enough.

Some smaller tests that I did went well. For example, I ate a gluten-free bun with filet Americain, a raw beef spread (yes I said raw) that we love in the Netherlands.

It had some garlic and onion in it, but it didn’t give me any problems! And oh man, I loved eating filet Americain again. I used to love it and I didn’t have it for four years.

FODMAP supplements -

My own experience is that I can tolerate small amounts of garlic, onion, wheat, etc. with these supplements. Perfect for when you go to a restaurant and you are not sure if something contains onion or garlic. If you want to put something on your gluten-free sandwich that is not entirely low FODMAP or if you feel like using ready-made pesto in your pasta.

I did notice that I still have to be very careful. My stomach is quite sensitive, if I eat too much in a restaurant, I already get stomach problems.

A supplement cannot do much against that. Having these supplements doesn’t mean that I can suddenly eat everything again without thinking about it, but I think that shouldn’t be the goal of using these supplements anyway.

I can recommend to everybody to try the FODMAP enzymes from Intoleran. And to see if they do anything for you.

If you are sensitive to one or more of the 4 FODMAP groups that these supplements are suitable for (there is no supplement for sorbitol and mannitol, the polyols) these supplements can be a lifesaver.

If they work well for you, they can make social events a lot easier.

Intoleran sells their FODMAP enzymes internationally through their website

I am very curious if you already knew about these supplements and if you have tested them! How were the results for you?

Gearchiveerd onder:


  • Val Rives says:

    I would like to read the information on the Disolut website but I don’t know this language. How do I change to English?

  • Julie says:

    Does anyone know if a similar supplement is available in the USA? I’ve long taken Lactaid and Beano but would love to find something for fructans.

    • Karlijn says:

      Disolut also ships to the US, so you could give that a try

    • Cat says:

      My daughter has fructose/fructan malabsorption and takes Eat Anything RX when she must eat trigger foods. Two pills just before the meal make a huge difference. I really don’t trust supplements because they are unregulated, but we were desperate and these turned out to be a life-changer. They don’t last super long, maybe 30-45 minutes.

  • Leah says:

    I think I know why they didnt work like you expected. The enzyme that breaks down beans alpha-galactosidase do not break down fructans like the manufacturer claim they do. It digest beans (GOS). Many of the foods we must avoid on this diet is those containing fructans, and there is no enzyme available to digest that, unfortunately

    • Robert says:

      This is absolutely true. There is zero peer-reviewed scientific evidence that it works on fructans. The truth is, nothing does. I miss onions so much!

      • William says:

        Inulinase will work on fructans according to the research I’ve seen. Unfortunately, I have found no products containing this enzyme yet.

    • Leah says:

      Yes, i wanted to say the same thing. Very bad misinformation actually. Now finally there is a company that makes the enzyme that digest wheat, onions etc. The enzyme is in the product Fodzyme is selling.

  • Casila says:

    Thanks I am looking for something to help with capsicum intolerance when eating out. It seems to be in everything nowadays.

  • carolyn S Barnett says:

    I really need help in what to purchase and how to take it, I’ve read the blog but need to know if I am making something with a fodmap in it if and when I should take a pill erc

  • Peter says:

    Did you find 3tablets helped with onion?

    • Karlijn says:

      For me they do help! I usually still end up feeling a bit bloated, but I have that very quickly. It definitely helps me to get little symptoms instead of a lot.

  • Leah says:

    To my knowledge alpha galactosidase does not digest fructans in onion and garlic, but it digests beans. Beano contains the same enzyme. It is inulinase that digest fructans so no wonder you got stomach pain from eating onion. I just found out that there is a company that sells inulinase now. So it may be possible to eat onion, garlic and brussel sbrout if we get our hands on their product:)

  • Terri Sidell says:

    Thanks, Karlijns for the review on Intolerance Enzymes. I have spent hours reading what all the FODMAP enzyme companies have put in their products. I Have only tried 3-FODZYME, I was able to eat a steak with onion & garlic powder and no problems, but it doesn’t have enough Lactase in it. FODMATE has 10,000 ALU Lactase, and many other enzymes, but doesn’t state what Proprietary Enzyme Blend is. It is a well-rounded FODMAP supplement like Intolerance. I still need an enzyme that covers Lipase. Many people like me with IBS have trouble digesting fats.
    I just ordered Enzymeduca Lacto, which has Lipase in it as well as other FODMAP enzymes. Another product I have tried is omne Diem-Fructose Digest. It has Xylose Isomerase in it. I tried it with low-fodmap fruits. Perhaps it would have been better to try it with an Apple rather than dried dates or kiwi, because it didn’t seem to have any effect.

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